University of Toronto Rövid összefoglaló The aim of this study is to assess the impact of Schistosoma mansoni infection and its treatment on genital immunology and HIV susceptibility in Ugandan women. Részletes leírás Schistosomiasis uganda mansoni is a water-borne disease caused by helminth Schistosoma mansoni S.
A recent epidemiological study found an association between S. Furthermore, in primate studies S.
While S. Therefore in this study we propose to explore whether S.
HIV-uninfected adult women from Entebbe, Uganda will be screened for schistosomiasis using a commercial CCA rapid test kit, and infected women who fulfill the study eligibility criteria will be recruited into the study. Kato-Katz microscopy analysis will be performed to assess egg shedding at baseline.
Additionally, urine microscopy will be done to screen for Schistosoma hematobium which can directly involve the genital mucosa. Schistosomiasis treatment will be provided to all participants according to Ugandan clinical guidelines.
Endocervical cytobrush, vaginal SoftCup and blood samples will be collected at three time points; at baseline and 4 and 8 weeks after schistosomiasis treatment, at the same stage of the menstrual cycle. Using an ex vivo HIV entry schistosomiasis uganda and mucosal cytokine and microbiome analyses we will quantify the effect of S. Átfogó állapot.